概述

  • 产品名称Anti-Ube2M抗体
    参阅全部 UBE2M 一抗
  • 描述
    小鼠单克隆抗体to Ube2M
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-184 of Human Ube2M

性能

应用

Our Abpromise guarantee covers the use of ab56383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 21 kDa.

靶标

  • 功能Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
  • 通路Protein modification; protein neddylation.
  • 序列相似性Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
  • 结构域Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hUbc12 antibody
    • NEDD8 carrier protein antibody
    • NEDD8 conjugating enzyme Ubc12 antibody
    • NEDD8 protein ligase antibody
    • NEDD8-conjugating enzyme Ubc12 antibody
    • UBC-RS2 antibody
    • UBC12 antibody
    • UBC12_HUMAN antibody
    • ube2m antibody
    • ubiquitin carrier protein M antibody
    • Ubiquitin conjugating enzyme E2 M antibody
    • Ubiquitin-conjugating enzyme E2 M antibody
    • ubiquitin-protein ligase M antibody
    • yeast UBC12 homolog antibody
    see all

Anti-Ube2M antibody 图像



  • Predicted band size : 21 kDa
    Ube2M antibody (ab56383) at 1ug/lane + Jurkat cell lysate at 25ug/lane.

Anti-Ube2M antibody (ab56383)参考文献

This product has been referenced in:
  • Xie P  et al. The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis. Nat Commun 5:3733 (2014). Read more (PubMed: 24821572) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab56383.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"