Anti-UBE2C抗体[EPR5161(2)] (ab125002)


  • 产品名称Anti-UBE2C抗体[EPR5161(2)]
    参阅全部 UBE2C 一抗
  • 描述
    兔单克隆抗体[EPR5161(2)] to UBE2C
  • 经测试应用适用于: WBmore details
    不适用于: Flow Cyt,ICC,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human UBE2C.

  • 阳性对照
    • SW480, HeLa, MCF7 and 293T cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab125002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).
  • 应用说明Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • 靶标

    • 功能Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Belongs to the ubiquitin-conjugating enzyme family.
    • 翻译后修饰Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cyclin selective ubiquitin carrier protein antibody
      • dJ447F3.2 antibody
      • Mitotic specific ubiquitin conjugating enzyme antibody
      • UB E2C antibody
      • UBCH 10 antibody
      • UbcH10 antibody
      • UBE 2C antibody
      • Ube2c antibody
      • UBE2C_HUMAN antibody
      • Ubiquitin carrier protein C antibody
      • Ubiquitin carrier protein E2 C antibody
      • Ubiquitin carrier protein E2C antibody
      • Ubiquitin conjugating enzyme E2 C antibody
      • Ubiquitin conjugating enzyme E2C antibody
      • Ubiquitin protein ligase C antibody
      • Ubiquitin-conjugating enzyme E2 C antibody
      • Ubiquitin-protein ligase C antibody
      see all

    Anti-UBE2C antibody [EPR5161(2)] 图像

    • All lanes : Anti-UBE2C antibody [EPR5161(2)] (ab125002) at 1/1000 dilution

      Lane 1 : SW480 cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : MCF7 cell lysate
      Lane 4 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 20 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-UBE2C antibody [EPR5161(2)] (ab125002)参考文献

    ab125002 has not yet been referenced specifically in any publications.

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