Anti-Ube2B抗体(ab96848)
Key features and details
- Rabbit polyclonal to Ube2B
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-Ube2B抗体
参阅全部 Ube2B 一抗 -
描述
兔多克隆抗体to Ube2B -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat, Zebrafish -
免疫原
Recombinant fragment, corresponding to a region within amino acids 1 and 152 of Human Ube2B (NP_003328)
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阳性对照
- HeLa and NIH-3T3 whole cell lysate. HepG2 cell line.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96848于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 17 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 17 kDa. |
靶标
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功能
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. -
通路
Protein modification; protein ubiquitination. -
序列相似性
Belongs to the ubiquitin-conjugating enzyme family. -
细胞定位
Cell membrane. Nucleus. In peripheral neurons, expressed both at the plasma membrane and in nuclei. - Information by UniProt
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数据库链接
- Entrez Gene: 7320 Human
- Entrez Gene: 22210 Mouse
- Entrez Gene: 81816 Rat
- Omim: 179095 Human
- SwissProt: P63146 Human
- SwissProt: P63147 Mouse
- SwissProt: P63149 Rat
- Unigene: 612096 Human
see all -
别名
- E2 17kDa antibody
- E2 protein antibody
- hHR6B antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab96848 尚未被引用在任何文献中。