概述

  • 产品名称Anti-Ube2B抗体
    参阅全部 Ube2B 一抗
  • 描述
    小鼠多克隆抗体to Ube2B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-152 of Human Ube2B

  • 阳性对照
    • UBE2B transfected mammalian cell lysate

应用

Our Abpromise guarantee covers the use of ab67118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 17 kDa (predicted molecular weight: 17 kDa).

靶标

  • 功能Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the ubiquitin-conjugating enzyme family.
  • 细胞定位Cell membrane. Nucleus. In peripheral neurons, expressed both at the plasma membrane and in nuclei.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E2 17kDa antibody
    • E2 protein antibody
    • hHR6B antibody
    • HR6B antibody
    • RAD6 homolog B antibody
    • RAD6B antibody
    • UBC2 antibody
    • UBE2B antibody
    • UBE2B_HUMAN antibody
    • Ubiquitin carrier protein B antibody
    • Ubiquitin conjugating enzyme E2 B antibody
    • Ubiquitin conjugating enzyme E2B (RAD6 homolog) antibody
    • Ubiquitin conjugating enzyme E2B antibody
    • Ubiquitin protein ligase B antibody
    • Ubiquitin-conjugating enzyme E2 17 kDa antibody
    • Ubiquitin-conjugating enzyme E2 B antibody
    • Ubiquitin-conjugating enzyme E2-17 kDa antibody
    • Ubiquitin-protein ligase B antibody
    see all

Anti-Ube2B antibody 图像

  • All lanes : Anti-Ube2B antibody (ab67118) at 1/500 dilution

    Lane 1 : UBE2B transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

    Predicted band size : 17 kDa
    Observed band size : 17 kDa

Anti-Ube2B antibody (ab67118)参考文献

ab67118 has not yet been referenced specifically in any publications.

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