Anti-UBASH3A抗体(ab105058)

概述

  • 产品名称
    Anti-UBASH3A抗体
    参阅全部 UBASH3A 一抗
  • 描述
    兔多克隆抗体to UBASH3A
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 434-483 (PCSLPRRSRG IKDFENDPPL SSCGIFQSRI AGDALLDSGI RISSVFASPA) of Human UBASH3A (NP_061834).

  • 阳性对照
    • Human Placenta lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab105058 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 74 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
  • 组织特异性
    Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
  • 序列相似性
    Contains 1 SH3 domain.
    Contains 1 UBA domain.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cbl interacting protein 4 antibody
    • Cbl-interacting protein 4 antibody
    • CLIP4 antibody
    • STS 2 antibody
    • STS-2 antibody
    • Suppressor of T cell receptor signaling 2 antibody
    • Suppressor of T-cell receptor signaling 2 antibody
    • T cell ubiquitin ligand antibody
    • T cell ubiquitin ligand protein antibody
    • T-cell ubiquitin ligand 1 antibody
    • TULA antibody
    • TULA-1 antibody
    • UBASH3A antibody
    • ubiquitin associated and SH3 domain containing, A antibody
    • Ubiquitin-associated and SH3 domain-containing protein A antibody
    • UBS3A_HUMAN antibody
    see all

Anti-UBASH3A antibody 图像

  • Anti-UBASH3A antibody (ab105058) at 1 µg/ml + Human Placenta Lysate at 10 µg

    Predicted band size : 74 kDa

实验方案

Anti-UBASH3A antibody (ab105058)参考文献

ab105058 has not yet been referenced specifically in any publications.

Product Wall

Abreviews
Abcam has not validated the combination of species/application used in this Abreview.
Application
Western blot
Sample
Mouse Cell lysate - whole cell (thymocytes peripheral CD4 T cells)
Gel Running Conditions
Reduced Denaturing (7-15%)
Loading amount
2e+006 cells
Treatment
pervanadate
Specification
thymocytes peripheral CD4 T cells
Blocking step
Milk as blocking agent for 45 minute(s) · Concentration: 5% · Temperature: 22°C
Username

Mr. Gaetan Blaize

Verified customer

提交于 Jun 26 2017

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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