概述

  • 产品名称Anti-UACA抗体
    参阅全部 UACA 一抗
  • 描述
    兔多克隆抗体to UACA
  • 经测试应用适用于: IP, IHC-Pmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region between residue 675-725 (KAKLAQHVKP EEHEQVKSRL EQKSGELGKK ITELTLKNQT LQKEIEKVYL D) of Human UACA (NP_060473.2).

  • 阳性对照
    • HeLa whole cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: Tris citrate/phosphate buffer, pH 7-8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab99321 was affinity purified using an epitope specific to UACA immobilized on solid support.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab99321 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
IHC-P Use at an assay dependent concentration.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
      Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury.
    • 组织特异性Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
    • 序列相似性Contains 6 ANK repeats.
    • 细胞定位Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Expressed diffusely in cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • FLJ10128 antibody
      • KIAA1561 antibody
      • MGC141967 antibody
      • MGC141969 antibody
      • Nuclear membrane binding protein antibody
      • NUCLING antibody
      • UACA antibody
      • UACA_HUMAN antibody
      • Uveal autoantigen with coiled coil domains and ankyrin repeats antibody
      • Uveal autoantigen with coiled-coil domains and ankyrin repeats antibody
      see all

    Anti-UACA antibody 图像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling UACA with ab99321 at 1/1000 (1µg/ml). Detection: DAB.
    • Detection of UACA in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab99321 at 3 µg/mg lysate for IP. ab99323, at 1 µg/ml, was used for subsequent Western blot detection. Detection: Chemiluminescence with an exposure time of 3 seconds.

    Anti-UACA antibody (ab99321)参考文献

    ab99321 has not yet been referenced specifically in any publications.

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