概述

  • 产品名称
    U 73122
  • 描述
    Standard phospholipase C (PLC) inhibitor
  • 生物学描述
    Standard phospholipase C inhibitor (PLC) (IC50 = ~6 µM at PLC-β3). Shows a variety of biological activities including antiplatelet activation, Ca2+ signaling modulation and inhibition of 5-lipoxygenase activity. Active in vivo.
  • 纯度
    > 98%

性能

  • 化学名称
    1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
  • 分子量
    464.65
  • 化学结构
    Chemical Structure
  • 分子式
    C29H40N2O3
  • CAS编号
    112648-68-7
  • PubChem识别号
    104794
  • 存放说明
    Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in DMSO to 10 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC
  • 来源

    Synthetic

文献

This product has been referenced in:
  • Liang WZ  et al. The mechanism of honokiol-induced intracellular Ca(2+) rises and apoptosis in human glioblastoma cells. Chem Biol Interact 221C:13-23 (2014). Read more (PubMed: 25106108) »
  • Shen W  et al. The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. J Nutr 143:584-90 (2013). Read more (PubMed: 23468551) »
  • Burgdorf C  et al. U73122, an aminosteroid phospholipase C inhibitor, is a potent inhibitor of cardiac phospholipase D by a PIP2-dependent mechanism. J Cardiovasc Pharmacol 55:555-9 (2010). Read more (PubMed: 20179606) »
  • Wilsher NE  et al. The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium. Drug Metab Dispos 35:1017-22 (2007). Read more (PubMed: 17403917) »
  • Hou C  et al. In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions. J Pharmacol Exp Ther 309:697-704 (2004). Read more (PubMed: 14730005) »
  • Muto Y  et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther 282:1379-88 (1997). Read more (PubMed: 9316850) »

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