Selective inhibitor of PGI2 synthase (IC50 = 2 μM) and TXA2 synthase. PGH2 analog. Partial agonist at TP receptors.
Store at -20°C (desiccating conditions).
Supplied in methyl acetate (5 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Gluais P et al. In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. Am J Physiol Heart Circ Physiol291:H2255-64 (2006).
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Zou M et al. Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. Br J Pharmacol126:1283-92 (1999).
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Mukhopadhyay A et al. Effect of trimetoquinol analogs for antagonism of endoperoxide/thromboxane A2-mediated responses in human platelets and rat aorta. J Pharmacol Exp Ther232:1-9 (1985).
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