Anti-Tyrosine Hydroxylase (phospho S40)抗体(ab51206)

概述

  • 产品名称Anti-Tyrosine Hydroxylase (phospho S40)抗体
    参阅全部 Tyrosine Hydroxylase 一抗
  • 描述
    兔多克隆抗体to Tyrosine Hydroxylase (phospho S40)
  • 特异性ab51206 detects endogenous levels of Tyrosine.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthesized phosphopeptide derived from human Tyrosine Hydroxylase around the phosphorylation site of serine 40 (R-Q-SP-L-I).

  • 阳性对照
    • Human brain tissue; extracts from RAW264.7 cells.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab51206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/300 - 1/1000. Detects a band of approximately 59 kDa (predicted molecular weight: 59 kDa).
ELISA 1/40000.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Plays an important role in the physiology of adrenergic neurons.
  • 组织特异性Mainly expressed in the brain and adrenal glands.
  • 通路Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • 疾病相关Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • 序列相似性Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Dystonia 14 antibody
    • DYT14 antibody
    • DYT5b antibody
    • EC 1.14.16.2 antibody
    • OTTHUMP00000011225 antibody
    • OTTHUMP00000011226 antibody
    • ple antibody
    • Protein Pale antibody
    • TH antibody
    • The antibody
    • TY3H_HUMAN antibody
    • TYH antibody
    • Tyrosine 3 hydroxylase antibody
    • Tyrosine 3 monooxygenase antibody
    • Tyrosine 3-hydroxylase antibody
    • Tyrosine 3-monooxygenase antibody
    • Tyrosine hydroxylase antibody
    see all

Anti-Tyrosine Hydroxylase (phospho S40) antibody 图像

  • This image shows human brain tissue stained with ab51206 at a dilution of 1/50-1/100. Right hand image: treated with immunising peptide; left hand image: untreated.
  • All lanes : Anti-Tyrosine Hydroxylase (phospho S40) antibody (ab51206)

    Lane 1 : Extracts from RAW264.7 cells treated with UV (30min) with immunising peptide
    Lane 2 : Extracts from RAW264.7 cells treated with UV (30min) with no immunising peptide


    Predicted band size : 59 kDa

Anti-Tyrosine Hydroxylase (phospho S40) antibody (ab51206)参考文献

This product has been referenced in:
  • Beccano-Kelly DA  et al. LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory. Hum Mol Genet 24:1336-49 (2015). Read more (PubMed: 25343991) »

See 1 Publication for this product

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