• 产品名称Anti-TYK2抗体
    参阅全部 TYK2 一抗
  • 描述
    兔多克隆抗体to TYK2
  • 特异性This antibody detects endogenous levels of TYK2 protein around Tyrosine 1054.
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from human TYK2 around the phosphorylation site of Tyrosine 1054.

  • 阳性对照
    • Human breast carcinoma tissue


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab39550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000.
IHC-P Use at an assay dependent concentration.


  • 功能Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
  • 组织特异性Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
  • 疾病相关Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
    Contains 1 FERM domain.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
  • 结构域The FERM domain mediates interaction with JAKMIP1.
  • Information by UniProt
  • 数据库链接
  • 别名
    • JTK 1 antibody
    • JTK1 antibody
    • Non receptor tyrosine protein kinase 2 antibody
    • Non receptor tyrosine protein kinase TYK2 antibody
    • Non-receptor tyrosine-protein kinase TYK2 antibody
    • OTTHUMP00000232745 antibody
    • OTTHUMP00000232746 antibody
    • OTTHUMP00000232748 antibody
    • Protein Tyrosine Kinase 2 antibody
    • TYK 2 antibody
    • Tyk2 antibody
    • TYK2_HUMAN antibody
    • Tyrosine kinase 2 antibody
    see all

Anti-TYK2 antibody 图像

  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using ab39550 (10-20µg/ml). Left: Untreated; Right: Treated with synthesized peptide.

Anti-TYK2 antibody (ab39550)参考文献

ab39550 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Western blot
Sample Salmo salar Cell lysate - whole cell (cell lines transfected with GFP-TYK2)
Loading amount 100000 cells
Specification cell lines transfected with GFP-TYK2
Gel Running Conditions Reduced Denaturing (4 - 12 %)
Blocking step (agent) for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

Abcam user community

Verified customer

提交于 Mar 03 2012

The codes will be activated only once we receive your Abreviews. As explained in a previous email, the testing offer works as follow : 1. Purchase the antibody to be tested. 2. Test the antibodies 3. Let us know the results, positiv...

Read More

The TYK2 antibody has not been tested yet in other application but IHC-P and ELISA. If it was not suitable for a tested application this information would appear on the datasheet. The monoclonal STAT1 antibody has the advantage to have no variabilit...

Read More

Thank you for providing this information. For the detection of TYK2, I selected the following antibodies : - ab39550 : non-phospho peptide around Tyr 1054. 79% when comparing the region aa 1045-1064 (which is not the exact immunogen seque...

Read More