Anti-TYK2抗体(ab39550)
Key features and details
- Rabbit polyclonal to TYK2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TYK2抗体
参阅全部 TYK2 一抗 -
描述
兔多克隆抗体to TYK2 -
宿主
Rabbit -
特异性
This antibody detects endogenous levels of TYK2 protein around Tyrosine 1054. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic non-phosphopeptide derived from human TYK2 around the phosphorylation site of Tyrosine 1054.
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阳性对照
- Human breast carcinoma tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab39550于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
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说明 |
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IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. -
组织特异性
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. -
疾病相关
Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain. -
结构域
The FERM domain mediates interaction with JAKMIP1. - Information by UniProt
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数据库链接
- Entrez Gene: 7297 Human
- Entrez Gene: 54721 Mouse
- Entrez Gene: 100361294 Rat
- Omim: 176941 Human
- SwissProt: P29597 Human
- SwissProt: Q9R117 Mouse
- Unigene: 75516 Human
- Unigene: 20249 Mouse
see all -
别名
- JTK 1 antibody
- JTK1 antibody
- Non receptor tyrosine protein kinase 2 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab39550 被引用在 2 文献中.
- Qin W et al. TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death. Cancer Med 8:5232-5241 (2019). PubMed: 31278855
- Hirbe AC et al. Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. Cancer 123:1194-1201 (2017). PubMed: 27875628