Ab16841 antibody is cross-reactive; it detects both TXNRD1 and TXNRD2. The antibody has been tested in western blotting in jurkat whole cell lysate, rat lung lysate, mouse liverlysate. In both rat and mouse lysates it detected two bands, the upper one being TXNRD2.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000. Predicted molecular weight: 56 kDa.
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low.
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Zhao X et al. Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats. Acta Biochim Biophys Sin (Shanghai)46:318-29 (2014).
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