Anti-TXNRD1抗体(ab113904)

概述

• 产品名称
  Anti-TXNRD1抗体
  参阅全部 TXNRD1 一抗
• 描述
  兔多克隆抗体to TXNRD1
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Cow, Dog, Pig, Chimpanzee, Macaque monkey, Gorilla, Orangutan
• 免疫原

  Synthetic peptide conjugated to KLH derived from within residues 250 - 350 of Human TXNRD1.

  参阅Abcam的专有抗源政策

• 阳性对照
  • This antibody gave a positive signal in Human Testis and Spleen tissue lysates as well as the following whole cell lysates: HeLa; HepG2; HEK293; MCF7.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  pH: 7.40
  Preservative: 0.02% Sodium azide
  Constituent: PBS
  Note: Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Cell Biology
  • Other Antibodies
  • Oxidative Stress

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
• 组织特异性
  Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
• 序列相似性
  Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  Contains 1 glutaredoxin domain.
• 结构域
  The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.
• 翻译后修饰
  The N-terminus of isoform 5 is blocked.
  ISGylated.
• 细胞定位
  Cytoplasm and Cytoplasm. Nucleus.

• Target information above from: UniProt accession Q16881 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 282388 Cow
  • Entrez Gene: 7296 Human
  • Entrez Gene: 396681 Pig
  • Omim: 601112 Human
  • SwissProt: O62768 Cow
  • SwissProt: Q16881 Human
  • SwissProt: Q9MYY8 Pig
• 别名
  • cytoplasmic antibody
  • Gene associated with retinoic and IFN-induced mortality 12 protein antibody
  • Gene associated with retinoic and interferon-induced mortality 12 protein antibody

  • Gene associated with retinoid IFN induced mortality 12 protein antibody
  • GRIM 12 antibody
  • GRIM-12 antibody
  • GRIM12 antibody
  • KDRF antibody
  • KM 102 derived reductase like factor antibody
  • KM-102-derived reductase-like factor antibody
  • MGC9145 antibody
  • Oxidoreductase antibody
  • Thioredoxin reductase 1 antibody
  • Thioredoxin reductase 1 cytoplasmic antibody
  • Thioredoxin reductase GRIM 12 antibody
  • Thioredoxin reductase TR1 antibody
  • TR 1 antibody
  • TR antibody
  • TR1 antibody
  • TRXR 1 antibody
  • TRXR1 antibody
  • TRXR1_HUMAN antibody
  • TXNR antibody
  • TXNRD 1 antibody
  • Txnrd1 antibody

  see all

实验方案

• Western blot protocols