概述

  • 产品名称Anti-TXNIP抗体
    参阅全部 TXNIP 一抗
  • 描述
    兔多克隆抗体to TXNIP
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between amino acids 300-350 of Human TXNIP (NP_006463.3).

  • 阳性对照
    • HeLa whole cell lysate

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应用

Our Abpromise guarantee covers the use of ab114981 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
    • 序列相似性Belongs to the arrestin family.
    • 翻译后修饰Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
    • 细胞定位Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EST01027 antibody
      • HHCPA78 antibody
      • THIF antibody
      • Thioredoxin binding protein 2 antibody
      • Thioredoxin interacting protein antibody
      • Thioredoxin-binding protein 2 antibody
      • Thioredoxin-interacting protein antibody
      • TXNIP antibody
      • TXNIP_HUMAN antibody
      • Upregulated by 1,25 dihydroxyvitamin D 3 antibody
      • VDUP1 antibody
      • Vitamin D3 up-regulated protein 1 antibody
      see all

    Anti-TXNIP antibody 图像

    • Detection of TXNIP in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab114981 at 6 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot detection. Detection: Chemiluminescence with an exposure time of 10 seconds.

    Anti-TXNIP antibody (ab114981)参考文献

    ab114981 has not yet been referenced specifically in any publications.

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