The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明Flow Cyt: Use 0.25µg for 105-8 cells in 100µl.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
组织特异性Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
序列相似性Belongs to the tumor necrosis factor family.
翻译后修饰The soluble form derives from the membrane form by proteolytic processing.
Staining of non transfected (1) and TWEAK transfected (2) L5178Y cells with 0.125 µg PE rat IgG1 isotype control (open histogram) or 0.125 µg ab93571 (colored histogram). Total viable cells were used for analysis.