概述

  • 产品名称
    Anti-TWEAK抗体[MTW-1] (Biotin)
    参阅全部 TWEAK 一抗
  • 描述
    大鼠单克隆抗体[MTW-1] to TWEAK (Biotin)
  • 偶联物
    Biotin
  • 经测试应用
    适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Full length Mouse TWEAK.

  • 阳性对照
    • Mouse TWEAK transfected L5178Y cells

性能

应用

Our Abpromise guarantee covers the use of ab95626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.125µg for 105-8 cells. A 100 µl volume is recommended for staining the cell sample.



ab18403-Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能
    Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
  • 组织特异性
    Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
  • 序列相似性
    Belongs to the tumor necrosis factor family.
  • 翻译后修饰
    The soluble form derives from the membrane form by proteolytic processing.
  • 细胞定位
    Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APO 3 ligand antibody
    • APO 3L antibody
    • APO3 ligand antibody
    • APO3/DR3 ligand antibody
    • APO3L antibody
    • DR3LG antibody
    • MGC129581 antibody
    • MGC20669 antibody
    • secreted form antibody
    • TNF-related weak inducer of apoptosis antibody
    • TNF12_HUMAN antibody
    • TNFSF 12 antibody
    • Tnfsf12 antibody
    • TNFSF12 protein antibody
    • Tumor necrosis factor (ligand) superfamily member 12 antibody
    • Tumor necrosis factor ligand superfamily member 12 antibody
    • Tumor necrosis factor superfamily member 12 antibody
    • TWEAK antibody
    • UNQ181/PRO207 antibody
    see all

图片

  • Staining of non-transfected (left) and TWEAK transfected (right) L5178Y cells with 0.06 µg of Rat IgG1 Isotype Control Biotin (open histogram) or 0.03 µg of ab95626 (filled histogram) followed by Streptavidin PE. Total viable cells were used for analysis.

文献

This product has been referenced in:
  • Nakayama M  et al. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem Biophys Res Commun 306:819-25 (2003). Read more (PubMed: 12821115) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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