概述

  • 产品名称Anti-TWEAK抗体
    参阅全部 TWEAK 一抗
  • 描述
    山羊多克隆抗体to TWEAK
  • 经测试应用适用于: Neutralising, WB, Indirect ELISA, Sandwich ELISAmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Highly pure (>98%) recombinant Human TWEAK.

性能

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应用

Our Abpromise guarantee covers the use of ab109824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Neutralising Use a concentration of 0.1 - 0.2 µg/ml. to yield one-half maximal inhibition inhibition [ND50] of the biological activity of Human TWEAK (200 ng/ml)
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 27 kDa. The detection limit for recombinant Human TWEAK is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
Indirect ELISA Use a concentration of 0.5 - 2 µg/ml. ab109824 allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human TWEAK (using 100 µl/well antibody solution).
Sandwich ELISA Use a concentration of 0.5 - 2 µg/ml. Can be paired for Sandwich ELISA with Goat polyclonal to TWEAK (Biotin) (ab83437). ab109824 in conjunction with ab83437 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human TWEAK (using 100 µl/well antibody solution).

靶标

  • 功能Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
  • 组织特异性Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 翻译后修饰The soluble form derives from the membrane form by proteolytic processing.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • APO 3 ligand antibody
    • APO 3L antibody
    • APO3 ligand antibody
    • APO3/DR3 ligand antibody
    • APO3L antibody
    • DR3LG antibody
    • MGC129581 antibody
    • MGC20669 antibody
    • secreted form antibody
    • TNF-related weak inducer of apoptosis antibody
    • TNF12_HUMAN antibody
    • TNFSF 12 antibody
    • Tnfsf12 antibody
    • TNFSF12 protein antibody
    • Tumor necrosis factor (ligand) superfamily member 12 antibody
    • Tumor necrosis factor ligand superfamily member 12 antibody
    • Tumor necrosis factor superfamily member 12 antibody
    • TWEAK antibody
    • UNQ181/PRO207 antibody
    see all

Anti-TWEAK antibody (ab109824)参考文献

This product has been referenced in:
  • Bover LC  et al. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol 178:8183-94 (2007). Read more (PubMed: 17548657) »

See 1 Publication for this product

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The immunogen sequence for antibody ab108924 is a E.coli expressed recombinant protein with sequence MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SAT...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"