概述

  • 产品名称Anti-TULP1抗体
    参阅全部 TULP1 一抗
  • 描述
    兔多克隆抗体to TULP1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment containing a sequence corresponding to a region within amino acids 281-520 of Human TULP1 (NP_003313).

  • 阳性对照
    • 293T, A431, H1299, HeLaS3, HepG2, Molt-4 and Raji whole cell lysates; Breast CA

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab97281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 61 kDa.
IHC-P 1/100 - 1/250.

靶标

  • 功能Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
  • 组织特异性Retina-specific.
  • 疾病相关Defects in TULP1 are the cause of retinitis pigmentosa type 14 (RP14) [MIM:600132]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP14 inheritance is autosomal recessive.
    Defects in TULP1 are the cause of Leber congenital amaurosis type 15 (LCA15) [MIM:613843]. LCA15 is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
  • 序列相似性Belongs to the TUB family.
  • 细胞定位Cytoplasm. Cell membrane. Secreted. Cell junction > synapse. Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway.
  • Information by UniProt
  • 数据库链接
  • 别名
    • RP14 antibody
    • Tubby like protein 1 antibody
    • Tubby related protein 1 (Tubby like protein 1) antibody
    • Tubby related protein 1 antibody
    • Tubby-like protein 1 antibody
    • Tubby-related protein 1 antibody
    • TUBL1 antibody
    • TULP 1 antibody
    • Tulp1 antibody
    • TULP1_HUMAN antibody
    see all

Anti-TULP1 antibody 图像

  • All lanes : Anti-TULP1 antibody (ab97281) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : H1299 whole cell lysate
    Lane 4 : HeLa S3 whole cell lysate
    Lane 5 : HepG2 whole cell lysate
    Lane 6 : Molt-4 whole cell lysate
    Lane 7 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 61 kDa
  • Immunohistochemical analysis of TULP1 in paraffin-embedded Breast CA, using ab97281 at 1/100 dilution.

Anti-TULP1 antibody (ab97281)参考文献

ab97281 has not yet been referenced specifically in any publications.

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