概述

  • 产品名称Anti-TUBB6抗体
    参阅全部 TUBB6 一抗
  • 描述
    兔多克隆抗体to TUBB6
  • 特异性The peptide used as the immunogen for the antibody is from Human TUBB6. The immunogen sequence suggests this antibody may cross-react with TUBB 1-5, although we have not tested this.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide between 146-174 amino acids from the central region of Human TUBB6 (NP_115914.1).

  • 阳性对照
    • K562 cell line lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度Protein A purified
  • 纯化说明This antibody is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab110592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 功能Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • 序列相似性Belongs to the tubulin family.
  • 结构域The highly acidic C-terminal region may bind cations such as calcium.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • tubulin beta-6 chain-like antibody
    • class V beta-tubulin antibody
    • HsT1601 antibody
    • TBB6_HUMAN antibody
    • TUBB-5 antibody
    • TUBB6 antibody
    • Tubulin beta 6 chain antibody
    • tubulin beta 6 class V antibody
    • tubulin beta class V antibody
    • tubulin beta MGC4083 antibody
    • Tubulin beta-6 antibody
    • Tubulin beta-6 chain antibody
    see all

Anti-TUBB6 antibody 图像

  • Anti-TUBB6 antibody (ab110592) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 50 kDa

Anti-TUBB6 antibody (ab110592)参考文献

ab110592 has not yet been referenced specifically in any publications.

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