概述

  • 产品名称
  • 描述
    兔多克隆抗体to TUBB6
  • 特异性
    The peptide used as the immunogen for the antibody is from Human TUBB6. The immunogen sequence suggests this antibody may cross-react with TUBB 1-5, although we have not tested this.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide between 146-174 amino acids from the central region of Human TUBB6 (NP_115914.1).

  • 阳性对照
    • K562 cell line lysates

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度
    Protein A purified
  • 纯化说明
    This antibody is purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 功能
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • 序列相似性
    Belongs to the tubulin family.
  • 结构域
    The highly acidic C-terminal region may bind cations such as calcium.
  • 翻译后修饰
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • 细胞定位
    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • tubulin beta-6 chain-like antibody
    • class V beta-tubulin antibody
    • HsT1601 antibody
    • TBB6_HUMAN antibody
    • TUBB-5 antibody
    • TUBB6 antibody
    • Tubulin beta 6 chain antibody
    • tubulin beta 6 class V antibody
    • tubulin beta class V antibody
    • tubulin beta MGC4083 antibody
    • Tubulin beta-6 antibody
    • Tubulin beta-6 chain antibody
    see all

图片

  • Anti-TUBB6 antibody (ab110592) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 50 kDa

实验方案

文献

ab110592 has not yet been referenced specifically in any publications.

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