概述

  • 产品名称Anti-TUBB2A抗体
    参阅全部 TUBB2A 一抗
  • 描述
    兔多克隆抗体to TUBB2A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 409-438 of Human TUBB2A (NP_001060.1).

  • 阳性对照
    • 293 cell line lysates.

性能

应用

Our Abpromise guarantee covers the use of ab116372 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 功能Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • 序列相似性Belongs to the tubulin family.
  • 翻译后修饰Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Class IIa beta tubulin antibody
    • dJ40E16.7 antibody
    • M(beta)2 antibody
    • TBB2A_HUMAN antibody
    • TUBB antibody
    • TUBB2 antibody
    • Tubb2a antibody
    • Tubulin beta 2 antibody
    • Tubulin beta 2A antibody
    • Tubulin beta 2A class IIa antibody
    • Tubulin beta polypeptide 2 antibody
    • Tubulin beta polypeptide antibody
    • Tubulin beta-2A chain antibody
    see all

Anti-TUBB2A antibody 图像

  • Anti-TUBB2A antibody (ab116372) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size : 50 kDa

Anti-TUBB2A antibody (ab116372)参考文献

ab116372 has not yet been referenced specifically in any publications.

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