概述

  • 产品名称Anti-TUBA8抗体
    参阅全部 TUBA8 一抗
  • 描述
    兔多克隆抗体to TUBA8
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 32-81 (ADGTFGTQAS KINDDDSFTT FSETGNGKHV RAVMVDLEPT VDEVRAG) of Mouse TUBA8 (NP_059075).

  • 阳性对照
    • Mouse spleen lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Constituents: 98% PBS, 2% Sucrose
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab113921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • 组织特异性Preferentially expressed in heart, skeletal muscle and testis. Expressed at low levels in the developing brain.
  • 疾病相关Defects in TUBA8 are the cause of polymicrogyria with optic nerve hypoplasia (PMGONH) [MIM:613180]. It is a disease characterized by extensive polymicrogyria, optic nerve hypoplasia, severe developmental delay, hypotonia, seizures, a dysplastic or absent corpus callosum and colpocephaly. Polymicrogyria is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination.
  • 序列相似性Belongs to the tubulin family.
  • 翻译后修饰Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha tubulin 8 antibody
    • Alpha-tubulin 8 antibody
    • TBA8_HUMAN antibody
    • Tuba8 antibody
    • TUBAL2 antibody
    • Tubulin alpha 8 chain antibody
    • Tubulin alpha chain like 2 antibody
    • Tubulin alpha chain-like 2 antibody
    • Tubulin alpha-8 chain antibody
    see all

Anti-TUBA8 antibody 图像

  • Anti-TUBA8 antibody (ab113921) at 1 µg/ml + Mouse spleen lysate at 10 µg

    Predicted band size : 50 kDa

Anti-TUBA8 antibody (ab113921)参考文献

ab113921 has not yet been referenced specifically in any publications.

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