概述

  • 产品名称Anti-TUBA6抗体
    参阅全部 TUBA6 一抗
  • 描述
    兔多克隆抗体to TUBA6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 421-449 of Human TUBA6 (NP_116093.1)

  • 阳性对照
    • K562 cell line lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab110810 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab110810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 功能Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • 序列相似性Belongs to the tubulin family.
  • 翻译后修饰Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
    Acetylation of alpha-tubulins at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha tubulin 6 antibody
    • Alpha tubulin isotype M alpha 6 antibody
    • Alpha-tubulin 6 antibody
    • bcm948 antibody
    • M[a]6 antibody
    • TBA1C_HUMAN antibody
    • Tuba1c antibody
    • Tubulin alpha 1C chain antibody
    • tubulin alpha 6 antibody
    • Tubulin alpha 6 chain antibody
    • Tubulin alpha-1C chain antibody
    • Tubulin alpha-6 chain antibody
    • tubulin, alpha 1c antibody
    see all

Anti-TUBA6 antibody 图像

  • Anti-TUBA6 antibody (ab110810) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 50 kDa

Anti-TUBA6 antibody (ab110810)参考文献

ab110810 has not yet been referenced specifically in any publications.

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