Anti-TUBA1 + TUBA3 + TUBA4抗体(ab110386)


  • 产品名称
    Anti-TUBA1 + TUBA3 + TUBA4抗体
    参阅全部 TUBA1 + TUBA3 + TUBA4 一抗
  • 描述
    兔多克隆抗体to TUBA1 + TUBA3 + TUBA4
  • 特异性
    ab110386 detects endogenous levels of total TUBA1 + TUBA3 + TUBA4 protein.
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Human
  • 免疫原

    A synthesized non-phosphopeptide derived from Human TUBA1 + TUBA3 + TUBA4 around the phosphorylation site of tyrosine 272 (A-T-YP-A-P).

  • 阳性对照
    • Rat brain cells lysate


  • 形式
  • 存放说明
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
  • 同种型
  • 研究领域


Our Abpromise guarantee covers the use of ab110386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 50 kDa.


  • 功能
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
  • 组织特异性
    Expressed at a high level in fetal brain.
  • 疾病相关
    Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.
  • 序列相似性
    Belongs to the tubulin family.
  • 翻译后修饰
    Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
    Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
    Acetylation of alpha-tubulins at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
  • 细胞定位
    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha-tubulin 3 antibody
    • H2 ALPHA antibody
    • TBA1A_HUMAN antibody
    • TUBA1A antibody
    • TUBA3C antibody
    • TUBA3D antibody
    • TUBA3E antibody
    • Tubulin alpha 3E chain antibody
    • Tubulin alpha-1A chain antibody
    • Tubulin alpha-3 chain antibody
    • Tubulin B-alpha-1 antibody
    • Tubulin, alpha 1a antibody
    • Tubulin, alpha 1b antibody
    • Tubulin, alpha 1c antibody
    • Tubulin, alpha 3c antibody
    • Tubulin, alpha 3e antibody
    see all

Anti-TUBA1 + TUBA3 + TUBA4 antibody 图像

  • All lanes : Anti-TUBA1 + TUBA3 + TUBA4 antibody (ab110386) at 1/500 dilution

    Lane 1 : Rat brain lysate
    Lane 2 : Rat brain lysate with blocking peptide at 10 µg

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 50 kDa


Anti-TUBA1 + TUBA3 + TUBA4 antibody (ab110386)参考文献

ab110386 has not yet been referenced specifically in any publications.

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