概述

  • 产品名称Anti-TTC8抗体
    参阅全部 TTC8 一抗
  • 描述
    兔多克隆抗体to TTC8
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 72-121 (NAIAQVPRPG TSLKLPGTNQ TGGPSQAVRP ITQAGRPITG FLRPSTQSGR) of Human TTC8 (NP_938052).

  • 阳性对照
    • THP-1 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in TTC8 are the cause of retinitis pigmentosa type 51 (RP51) [MIM:613464]. It is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    Defects in TTC8 are the cause of Bardet-Biedl syndrome type 8 (BBS8) [MIM:209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.
  • 序列相似性Contains 8 TPR repeats.
  • 细胞定位Cytoplasm > cytoskeleton > centrosome. Cell projection > cilium membrane. Cytoplasm. Localizes to nonmembranous centriolar satellites in the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Bardet Biedl syndrome 8 protein antibody
    • Bardet Biedl syndrome type 8 antibody
    • Bardet-Biedl syndrome 8 protein antibody
    • BBS8 antibody
    • RP51 antibody
    • Tetratricopeptide repeat domain 8 antibody
    • Tetratricopeptide repeat protein 8 antibody
    • TPR repeat protein 8 antibody
    • TTC 8 antibody
    • Ttc8 antibody
    • TTC8_HUMAN antibody
    see all

Anti-TTC8 antibody 图像

  • Anti-TTC8 antibody (ab89710) at 1 µg/ml (in 5% skim milk / PBS buffer) + THP-1 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 60 kDa

Anti-TTC8 antibody (ab89710)参考文献

ab89710 has not yet been referenced specifically in any publications.

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