Anti-TTC11/FIS1抗体(ab71498)
Key features and details
- Rabbit polyclonal to TTC11/FIS1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-TTC11/FIS1抗体
参阅全部 TTC11/FIS1 一抗 -
描述
兔多克隆抗体to TTC11/FIS1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- Jurkat cell lysates
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常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 3491R Fis1 Polyclonal Antibody.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 0.5% BSA, 30% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab71498于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 17 kDa (predicted molecular weight: 17 kDa).
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说明 |
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WB
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 17 kDa (predicted molecular weight: 17 kDa). |
靶标
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功能
Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. -
序列相似性
Belongs to the FIS1 family.
Contains 1 TPR repeat. -
结构域
The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L. -
翻译后修饰
Ubiquitinated by MARCH5. -
细胞定位
Mitochondrion outer membrane. Peroxisome membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 51024 Human
- Entrez Gene: 66437 Mouse
- Entrez Gene: 288584 Rat
- Omim: 609003 Human
- SwissProt: Q9Y3D6 Human
- SwissProt: Q9CQ92 Mouse
- SwissProt: P84817 Rat
- Unigene: 423968 Human
see all -
别名
- 2010003O14Rik antibody
- CGI 135 antibody
- CGI135 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (70)
ab71498 被引用在 70 文献中.
- Simula L et al. PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism. Mol Oncol 16:188-205 (2022). PubMed: 34535949
- Liu Z et al. Ginsenoside-Rg1 attenuates sepsis-induced cardiac dysfunction by modulating mitochondrial damage via the P2X7 receptor-mediated Akt/GSK-3β signaling pathway. J Biochem Mol Toxicol 36:e22885 (2022). PubMed: 34859534
- Andrianova NV et al. Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats. Int J Mol Sci 23:N/A (2022). PubMed: 36499550
- Liu M et al. Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis. Mol Oncol 15:2084-2105 (2021). PubMed: 33675143
- Nandi SS et al. Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1a Axis. Front Physiol 12:718982 (2021). PubMed: 34912235