概述

  • 产品名称Anti-TSSC3抗体
    参阅全部 TSSC3 一抗
  • 描述
    兔多克隆抗体to TSSC3
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 102-151 (QNRRALQDFR SRQERTAPAA PAEDAVAAAA AAPSEPSEPS RPSPQPKPRT) of Human TSSC3 (NP_003302).

  • 阳性对照
    • HT1080 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab99209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P 1/100.

靶标

  • 功能Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
  • 组织特异性Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
  • 序列相似性Belongs to the PHLDA2 family.
    Contains 1 PH domain.
  • 结构域The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3).
  • 细胞定位Cytoplasm. Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beckwith Wiedemann syndrome chromosome region 1 candidate protein C antibody
    • Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein antibody
    • BRW 1C antibody
    • BRW1C antibody
    • BWR 1C antibody
    • BWR1C antibody
    • HLDA 2 antibody
    • HLDA2 antibody
    • Imprinted in placenta and liver antibody
    • Imprinted in placenta and liver protein antibody
    • IPL antibody
    • p17 Beckwith Wiedemann region 1C antibody
    • p17 BWR1C antibody
    • p17-Beckwith-Wiedemann region 1 C antibody
    • p17-BWR1C antibody
    • PHLA2_HUMAN antibody
    • PHLDA 2 antibody
    • phlda2 antibody
    • Pleckstrin homology like domain family A member 2 antibody
    • Pleckstrin homology-like domain family A member 2 antibody
    • TSSC 3 antibody
    • Tumor suppressing STF cDNA 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment cDNA 3 antibody
    • Tumor suppressing subtransferable candidate 3 antibody
    • Tumor supressing STF cDNA 3 antibody
    • Tumor-suppressing STF cDNA 3 protein antibody
    • Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    see all

Anti-TSSC3 antibody 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human bronchial epithelial tissue labelling TSSC3 with ab99209 at 1/100. A Cy3-conjugate donkey anti-rabbit IgG (1/200) was used as the secondary antibody. Positive staining shown in the cytoplasm and membrane. Magnification: 20X. Exposure time: 0.5 - 2.0 seconds. Left - DAPI. Middle - TSSC3. Right - Merge.
  • Anti-TSSC3 antibody (ab99209) at 1 µg/ml + HT1080 cell lysate at 10 µg

    Predicted band size : 17 kDa
    Gel concentration 10-20%

Anti-TSSC3 antibody (ab99209)参考文献

This product has been referenced in:
  • Dai H  et al. TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. Carcinogenesis : (2011). WB ; Human . Read more (PubMed: 22021909) »

See 1 Publication for this product

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