概述

  • 产品名称Anti-TSSC3抗体
    参阅全部 TSSC3 一抗
  • 描述
    小鼠单克隆抗体to TSSC3
  • 经测试应用适用于: WB, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 1-111 of Human TSSC3

性能

应用

Our Abpromise guarantee covers the use of ab58379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml.
Flow Cyt Use 1µg for 106 cells. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
  • 组织特异性Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
  • 序列相似性Belongs to the PHLDA2 family.
    Contains 1 PH domain.
  • 结构域The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3).
  • 细胞定位Cytoplasm. Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beckwith Wiedemann syndrome chromosome region 1 candidate protein C antibody
    • Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein antibody
    • BRW 1C antibody
    • BRW1C antibody
    • BWR 1C antibody
    • BWR1C antibody
    • HLDA 2 antibody
    • HLDA2 antibody
    • Imprinted in placenta and liver antibody
    • Imprinted in placenta and liver protein antibody
    • IPL antibody
    • p17 Beckwith Wiedemann region 1C antibody
    • p17 BWR1C antibody
    • p17-Beckwith-Wiedemann region 1 C antibody
    • p17-BWR1C antibody
    • PHLA2_HUMAN antibody
    • PHLDA 2 antibody
    • phlda2 antibody
    • Pleckstrin homology like domain family A member 2 antibody
    • Pleckstrin homology-like domain family A member 2 antibody
    • TSSC 3 antibody
    • Tumor suppressing STF cDNA 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    • Tumor suppressing subchromosomal transferable fragment cDNA 3 antibody
    • Tumor suppressing subtransferable candidate 3 antibody
    • Tumor supressing STF cDNA 3 antibody
    • Tumor-suppressing STF cDNA 3 protein antibody
    • Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
    see all

Anti-TSSC3 antibody 图像

  • Western blot against tagged recombinant protein immunogen using ab58379 TSSC3 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa
  • Overlay histogram showing JEG3 cells stained with ab58379 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab58379, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 1µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-TSSC3 antibody (ab58379)参考文献

ab58379 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab58379.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"