概述

  • 产品名称
  • 描述
    兔多克隆抗体to TSPYL1
  • 经测试应用
    适用于: IHC-P, ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: AEEVKTGKCA TVSAAVAERE SAEVVVKEGL AEKEVMEEQM EVEEQPPEGE EIEVAEEDRL EEEAREEEGP WPLHEALRMD PLE, corresponding to amino acids of Human TSPYL1.

  • 阳性对照
    • Human kidney tissue; U 2 OS cells; RT 4, U 251 MG, Human liver and tonsil lysates.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab122200 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100
WB 1/250 - 1/500.

靶标

  • 组织特异性
    Expressed in testis, ovary, liver, spleen, brain, kidney, prostate, lung, liver, and heart.
  • 疾病相关
    Defects in TSPYL1 are the cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT) [MIM:608800]. SIDDT is an autosomal recessive disorder. Affected infants appear normal at birth, develop signs of visceroautonomic dysfunction early in life, and die before 12 months of age of abrupt cardiorespiratory arrest. Features included bradycardia, hypothermia, severe gastroesophageal reflux, laryngospasm, bronchospasm, and abnormal cardiorespiratory patterns during sleep. Genotypic males with SIDDT had fetal testicular dysgenesis and ambiguous genitalia, with findings such as intraabdominal testes, dysplastic testes, deficient fetal testosterone production, fusion and rugation of the gonadal sac, and partial development of the penile shaft. Female sexual development was normal. Affected infants had an unusual staccato cry, similar to the cry of a goat.
  • 序列相似性
    Belongs to the nucleosome assembly protein (NAP) family.
  • 细胞定位
    Nucleus > nucleolus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • SIDDT antibody
    • Testis specific like protein Y encoded antibody
    • Testis specific Y encoded like protein 1 antibody
    • Testis-specific Y-encoded-like protein 1 antibody
    • TSPY like antibody
    • TSPY like 1 antibody
    • TSPY like protein 1 antibody
    • TSPY-like protein 1 antibody
    • TSPYL antibody
    • TSPYL1 antibody
    • TSYL1_HUMAN antibody
    see all

图片

  • ab122200, at 1/1000 dilution, staining TSPYL1 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • ab122200, at 4 µg/ml, staining TSPYL1 in PFA/Triton X-100 fixed/permeabilized U 2 OS cells by Immunofluorescence (green).
  • All lanes : Anti-TSPYL1 antibody (ab122200) at 1/250 dilution

    Lane 1 : RT 4 lysate
    Lane 2 : U 251 MG lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique

文献

ab122200 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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