概述

  • 产品名称Anti-TSPAN12抗体
    参阅全部 TSPAN12 一抗
  • 描述
    兔多克隆抗体to TSPAN12
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 180-229 (SCCVREFPGC SKQAHQEDLS DLYQEGCGKK MYSFLRGTKQ LQVLRFLGIS) of Human TSPAN12 (NP_036470).

  • 阳性对照
    • Human fetal thymus lysate.

性能

应用

Our Abpromise guarantee covers the use of ab90091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. It is a regulator of cell surface receptor signal transduction and plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. It acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. It also acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. It activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP) and activates MMP14/MT1-MMP-dependent cleavage activity.
  • 细胞定位Cell membrane; Multi-pass membrane protein.
  • 数据库链接
  • 别名
    • 9030619E17 antibody
    • AI426782 antibody
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    • AW111457 antibody
    • MGC109305 antibody
    • NET 2 antibody
    • NET2 antibody
    • OTTHUMP00000211224 antibody
    • Tetraspan NET 2 antibody
    • Tetraspanin 12 antibody
    • Tetraspanin12 antibody
    • TM4SF12 antibody
    • Transmembrane 4 superfamily member 12 antibody
    • TSPAN 12 antibody
    see all

Anti-TSPAN12 antibody 图像

  • Anti-TSPAN12 antibody (ab90091) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal thymus lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 35 kDa

Anti-TSPAN12 antibody (ab90091)参考文献

ab90091 has not yet been referenced specifically in any publications.

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