概述

  • 产品名称Anti-TSEN2抗体
    参阅全部 TSEN2 一抗
  • 描述
    兔多克隆抗体to TSEN2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rabbit, Horse, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 395-444 (LRRPLSWKSL AALSRVSVNV SKELMLCYLI KPSTMTDKEM ESPECMKRIK) of Human TSEN2 (NP_079541).

  • 阳性对照
    • Human fetal heart lysate.

性能

应用

Our Abpromise guarantee covers the use of ab125383 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
  • 组织特异性Isoform 1 and isoform 2 are widely expressed at very low level.
  • 疾病相关Defects in TSEN2 are the cause of pontocerebellar hypoplasia type 2B (PCH2B) [MIM:612389]. Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. PCH type 2 is characterized by progressive microcephaly from birth combined with extrapyramidal dyskinesia and chorea, epilepsy, and normal spinal cord findings.
  • 序列相似性Belongs to the tRNA-intron endonuclease family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Nucleus > nucleolus. May be transiently localized in the nucleolus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • HsSen2 antibody
    • MGC2776 antibody
    • MGC4440 antibody
    • SEN2 antibody
    • SEN2_HUMAN antibody
    • SEN2L antibody
    • tRNA intron endonuclease Sen2 antibody
    • tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae) antibody
    • tRNA splicing endonuclease subunit Sen2 antibody
    • tRNA-intron endonuclease sen2 antibody
    • tRNA-splicing endonuclease subunit Sen2 antibody
    • TSEN 2 antibody
    • TSEN2 antibody
    see all

Anti-TSEN2 antibody 图像

  • Anti-TSEN2 antibody (ab125383) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Secondary
    Goat anti-Rabbit IgG HRP

    Predicted band size : 53 kDa

Anti-TSEN2 antibody (ab125383)参考文献

ab125383 has not yet been referenced specifically in any publications.

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