概述

  • 产品名称Anti-TRPM3抗体
    参阅全部 TRPM3 一抗
  • 描述
    兔多克隆抗体to TRPM3
  • 特异性ab32993 recognises Transient receptor potential cation channel subfamily M member 3 (TRPM3).
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    A region within synthetic peptide: YLRDTPPVPV VVCDGSGRAS DILAFGHKYS EEGGLINESL RDQLLVTIQK, corresponding to internal sequence amino acids 197-246 of Human TRPM3

  • 阳性对照
    • Jurkat cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab32993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/312500.
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 37 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性Transient receptor potential cation channel, subfamily M, member 3 (TRPM3) belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation selective channels important for cellular calcium signaling and homeostasis. TRPM3 mediates calcium entry, and this entry is potentiated by calcium store depletion. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. The TRPM3-mediated calcium entry is inhibited by the nonselective calcium channel blocker lanthanide gadolinium. Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • 细胞定位Membrane; multi pass membrane protein.
  • 数据库链接
  • 别名
    • GON2 antibody
    • long transient receptor potential channel 3 antibody
    • LTrpC 3 antibody
    • LTRPC3 antibody
    • melastatin 2 antibody
    • Melastatin2 antibody
    • MLSN2 antibody
    • transient receptor potential cation channel, subfamily M, member 3 antibody
    see all

Anti-TRPM3 antibody 图像

  • Anti-TRPM3 antibody (ab32993) at 2.5 µg/ml + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti Rabbit IgG at 1/50000 dilution

    Predicted band size : 37 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

Anti-TRPM3 antibody (ab32993)参考文献

ab32993 has not yet been referenced specifically in any publications.

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