概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 额外的序列信息14 amino acids near the amino terminus of human TRPC6.

相关产品

技术指标

Our Abpromise guarantee covers the use of ab106953 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-TRPC6 antibody (ab62461)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • bZ1P14.9
    • FLJ11098
    • FLJ14863
    • FSGS2
    • MTRP6
    • Short transient receptor potential channel 6
    • si:rp71-1p14.9
    • Transient receptor potential cation channel subfamily C member 6
    • Transient receptor protein 6
    • TRP 6
    • TRP-6
    • TRP6
    • TRPC 6
    • Trpc6
    • TRPC6_HUMAN
    • TRRP6
    see all
  • 功能Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
  • 组织特异性Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
  • 疾病相关Defects in TRPC6 are the cause of focal segmental glomerulosclerosis type 2 (FSGS2) [MIM:603965]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • 序列相似性Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
    Contains 4 ANK repeats.
  • 细胞定位Membrane.
  • Information by UniProt

TRPC6 peptide (ab106953)参考文献

ab106953 has not yet been referenced specifically in any publications.

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