概述

  • 产品名称Anti-TRPC4抗体
    参阅全部 TRPC4 一抗
  • 描述
    山羊多克隆抗体to TRPC4
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Cow, Human
  • 免疫原

    Synthetic peptide:

    KHAKEEDSSIDYD

    by a Cysteine residue linker, corresponding to C terminal amino acids 948-960 of TRPC4

  • 阳性对照
    • Rat brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab82133 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 112 kDa).
ELISA Use at an assay dependent dilution.

靶标

  • 功能Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
  • 组织特异性Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
  • 序列相似性Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
    Contains 4 ANK repeats.
  • 结构域The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
    The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1.
    The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5.
  • 翻译后修饰Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.
  • 细胞定位Membrane. Cell membrane. Enhanced insertion into the cell membrane after activation of the EGF receptor.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CCE1 antibody
    • HTRP 4 antibody
    • hTrp-4 antibody
    • hTrp4 antibody
    • MGC119570 antibody
    • MGC119571 antibody
    • MGC119572 antibody
    • MGC119573 antibody
    • RP11-10M8.1 antibody
    • Short transient receptor potential channel 4 antibody
    • STRPC4 antibody
    • Transient receptor potential 4 antibody
    • transient receptor potential cation channel subfamily C antibody
    • Transient receptor potential cation channel subfamily C member 4 antibody
    • transient receptor potential channel 4 antibody
    • TRP 4 antibody
    • trp related protein 4 antibody
    • Trp-related protein 4 antibody
    • TRP4 antibody
    • TRPC 4 antibody
    • TrpC4 antibody
    • TRPC4 protein antibody
    • TRPC4_HUMAN antibody
    see all

Anti-TRPC4 antibody 图像

  • Anti-TRPC4 antibody (ab82133) at 0.3 µg/ml + Rat brain lysate 35 ug in RIPA buffer

    Predicted band size : 112 kDa

Anti-TRPC4 antibody (ab82133)参考文献

ab82133 has not yet been referenced specifically in any publications.

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