Anti-TRP1抗体[Ta99], prediluted (ab11781)

概述

  • 产品名称Anti-TRP1抗体[Ta99], prediluted
    参阅全部 TRP1 一抗
  • 描述
    小鼠单克隆抗体[Ta99] to TRP1, prediluted
  • 特异性This monoclonal antibody detects a differentiation related, pigmentation-associated glycoprotein (gp75), expressed by melanoma cells, nomal melanocytes and nevi. This antibody does not react with carcinomas and sarcomas.
  • 经测试应用适用于: IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    SK-MEL-23 Melanoma cell line

  • 阳性对照
    • Human melanoma or normal skin. Normal mouse serum is included with this product as a negative control.

性能

应用

Our Abpromise guarantee covers the use of ab11781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr
  • 应用说明IHC-Fr: Use at an assay dependent dilution. For optimal staining, the primary antibody should be incubated 20-60 minutes at room temperature.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
    • 组织特异性Pigment cells.
    • 通路Pigment biosynthesis; melanin biosynthesis.
    • 疾病相关Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
    • 序列相似性Belongs to the tyrosinase family.
    • 细胞定位Melanosome membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 5 antibody
      • 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody
      • 6-dihydroxyindole-2-carboxylic acid oxidase antibody
      • b-PROTEIN antibody
      • CAS2 antibody
      • Catalase B antibody
      • CATB antibody
      • DHICA oxidase antibody
      • Glycoprotein 75 antibody
      • GP75 antibody
      • Melanoma antigen gp75 antibody
      • OCA3 antibody
      • TRP antibody
      • TRP-1 antibody
      • TRP1 antibody
      • Tyrosinase related protein 1 antibody
      • Tyrosinase-related protein 1 antibody
      • TYRP antibody
      • TYRP1 antibody
      • TYRP1_HUMAN antibody
      • TYRRP antibody
      see all

    Anti-TRP1 antibody [Ta99], prediluted (ab11781)参考文献

    ab11781 has not yet been referenced specifically in any publications.

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