概述

  • 产品名称Anti-TRP1抗体
    参阅全部 TRP1 一抗
  • 描述
    小鼠多克隆抗体to TRP1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein corresponding to Human TRP1.

  • 阳性对照
    • Pancreas or A431 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab89635 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 61 kDa.

靶标

  • 功能Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
  • 组织特异性Pigment cells.
  • 通路Pigment biosynthesis; melanin biosynthesis.
  • 疾病相关Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
  • 序列相似性Belongs to the tyrosinase family.
  • 细胞定位Melanosome membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 5 antibody
    • 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody
    • 6-dihydroxyindole-2-carboxylic acid oxidase antibody
    • b-PROTEIN antibody
    • CAS2 antibody
    • Catalase B antibody
    • CATB antibody
    • DHICA oxidase antibody
    • Glycoprotein 75 antibody
    • GP75 antibody
    • Melanoma antigen gp75 antibody
    • OCA3 antibody
    • TRP antibody
    • TRP-1 antibody
    • TRP1 antibody
    • Tyrosinase related protein 1 antibody
    • Tyrosinase-related protein 1 antibody
    • TYRP antibody
    • TYRP1 antibody
    • TYRP1_HUMAN antibody
    • TYRRP antibody
    see all

Anti-TRP1 antibody 图像

  • Anti-TRP1 antibody (ab89635) at 1 µg/ml + Human pancreas lysate at 50 µg

    Predicted band size : 61 kDa
  • Anti-TRP1 antibody (ab89635) at 1 µg/ml + A431 cell lysate at 50 µg

    Predicted band size : 61 kDa
  • All lanes : Anti-TRP1 antibody (ab89635) at 1 µg/ml

    Lane 1 : Tyrosinase Related Protein 75 transfected 293T cell lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 61 kDa

Anti-TRP1 antibody (ab89635)参考文献

This product has been referenced in:
  • Miyagishima KJ  et al. In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications. Stem Cells Transl Med 5:1562-1574 (2016). Read more (PubMed: 27400791) »

See 1 Publication for this product

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