Anti-Troponin I fast + slow skeletal muscle抗体[12F10] (ab110132)

概述

  • 产品名称
    Anti-Troponin I fast + slow skeletal muscle抗体[12F10]
  • 描述
    小鼠单克隆抗体[12F10] to Troponin I fast + slow skeletal muscle
  • 特异性
    Cross-reactivity with Cardiac Troponin I is less than 0.05%.
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Human
  • 免疫原

    Mouse Troponin I fast + slow skeletal muscle.

  • 阳性对照
    • Human skeletal muscle tissue.
  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.

性能

应用

Our Abpromise guarantee covers the use of ab110132 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 21 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 相关性
    Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue.
  • 细胞定位
    Cytoplasmic and Nuclear
  • 数据库链接
  • 别名
    • AMCD2B antibody
    • DA2B antibody
    • DKFZp451O223 antibody
    • Fast twitch skeletal muscle troponin I antibody
    • FSSV antibody
    • fsTnI antibody
    • OTTHUMP00000014141 antibody
    • OTTHUMP00000014142 antibody
    • OTTHUMP00000014143 antibody
    • OTTHUMP00000033877 antibody
    • OTTHUMP00000033909 antibody
    • OTTHUMP00000033910 antibody
    • SSTNI antibody
    • TNN1 antibody
    • Troponin I fast twitch 2 antibody
    • Troponin I type 1 (skeletal, slow) antibody
    • Troponin I type 2 (skeletal, fast) antibody
    • Troponin I, fast skeletal muscle antibody
    • Troponin I, fast twitch isoform antibody
    • Troponin I, fast twitch skeletal muscle isoform antibody
    • Troponin I, skeletal, fast antibody
    • Troponin I, slow skeletal muscle antibody
    • Troponin I, slow twitch isoform antibody
    see all

图片

  • ab110132 at 10 µg/ml staining Troponin I fast + slow skeletal muscle in Formalin-Fixed, Paraffin-Embedded Human skeletal muscle tissue by Immunohistochemistry. Detection utilised biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

文献

ab110132 has not yet been referenced specifically in any publications.

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