Anti-Tropomyosin 3抗体(ab87258)

概述

  • 产品名称Anti-Tropomyosin 3抗体
    参阅全部 Tropomyosin 3 一抗
  • 描述
    兔多克隆抗体to Tropomyosin 3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Chimpanzee, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 144-193 (EERAELAESR CREMDEQIRL MDQNLKCLSA AEEKYSQKED KYEEEIKILT) of Human Tropomyosin 3 (NP_705935).

  • 阳性对照
    • THP-1 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab87258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
  • 疾病相关Defects in TPM3 are the cause of nemaline myopathy type 1 (NEM1) [MIM:609284]. A form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Autosomal dominant nemaline myopathy type 1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate-to-severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
    Defects in TPM3 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving TPM3 is found in thyroid papillary carcinomas. A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.
  • 序列相似性Belongs to the tropomyosin family.
  • 结构域The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha tropomyosin 3 antibody
    • Alpha tropomyosin slow skeletal antibody
    • CFTD antibody
    • Cytoskeletal tropomyosin TM30 antibody
    • FLJ41118 antibody
    • gamma TM antibody
    • Gamma tropomyosin antibody
    • Gamma-tropomyosin antibody
    • Heat stable cytoskeletal protein 30 kDa antibody
    • hscp30 antibody
    • hTM30nm antibody
    • hTM5 antibody
    • hTMnm antibody
    • MGC102590 antibody
    • MGC14582 antibody
    • MGC3261 antibody
    • MGC72094 antibody
    • NEM1 antibody
    • OK/SW-cl.5 antibody
    • OTTHUMP00000034019 antibody
    • OTTHUMP00000034171 antibody
    • OTTHUMP00000034172 antibody
    • TM 5 antibody
    • TM-5 antibody
    • TM3 antibody
    • TM30 antibody
    • TM30nm antibody
    • TM5 antibody
    • Tm5NM antibody
    • Tpm 5 antibody
    • TPM3 antibody
    • TPM3/NTRK1 FUSION GENE, INCLUDED antibody
    • TPM3_HUMAN antibody
    • Tpm5 antibody
    • TPMsk3 antibody
    • TRK antibody
    • TRK ONCOGENE, INCLUDED antibody
    • Trop 5 antibody
    • Tropomyosin 3 antibody
    • Tropomyosin 3 gamma antibody
    • Tropomyosin 5 antibody
    • Tropomyosin alpha 3 chain antibody
    • Tropomyosin alpha-3 chain antibody
    • Tropomyosin gamma antibody
    • Tropomyosin-3 antibody
    • Tropomyosin-5 antibody
    see all

Anti-Tropomyosin 3 antibody 图像

  • Anti-Tropomyosin 3 antibody (ab87258) at 1 µg/ml (in 5% skim milk / PBS buffer) + THP-1 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 33 kDa
    Observed band size : 33 kDa
    Additional bands at : 53 kDa. We are unsure as to the identity of these extra bands.

Anti-Tropomyosin 3 antibody (ab87258)参考文献

ab87258 has not yet been referenced specifically in any publications.

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