概述

  • 产品名称Anti-TrkC抗体
    参阅全部 TrkC 一抗
  • 描述
    兔多克隆抗体to TrkC
  • 特异性From experiments using similar antisera, it is anticipated that the reagent will block TrkC receptor binding of corresponding Nerve Growth factor ligand.
  • 经测试应用适用于: ICC/IF, IHC-Frmore details
    不适用于: WB
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Extracellular domain of Human TrkC.

  • 阳性对照
    • Rat peripheral sensory ganglia.

性能

应用

Our Abpromise guarantee covers the use of ab43078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/250.
IHC-Fr 1/3000.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
    • 组织特异性Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
    • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 2 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 protein kinase domain.
    • 翻译后修饰Ligand-mediated auto-phosphorylation.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EC 2.7.10.1 antibody
      • ETS related protein neurotrophic receptor tyrosine kinase fusion antibody
      • ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody
      • ETV6 NTRK3 fusion antibody
      • GP145 TrkC antibody
      • gp145(trkC) antibody
      • GP145-TrkC antibody
      • GP145TrkC antibody
      • Neurotrophic tyrosine kinase receptor type 3 antibody
      • Neurotrophin 3 receptor antibody
      • NT 3 growth factor receptor antibody
      • NT 3 growth factor receptor precursor antibody
      • NT 3 receptor antibody
      • NT-3 growth factor receptor antibody
      • Ntrk3 antibody
      • NTRK3_HUMAN antibody
      • OTTHUMP00000192915 antibody
      • TRK C antibody
      • Trk-C antibody
      • TRKC antibody
      • TrkC tyrosine kinase antibody
      • Tyrosine kinase receptor C antibody
      see all

    Anti-TrkC antibody (ab43078)参考文献

    This product has been referenced in:
    • Cesca F  et al. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ 19:194-208 (2012). Read more (PubMed: 22048155) »

    See 1 Publication for this product

    Product Wall

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Immunocytochemistry/ Immunofluorescence
    Sample Human Cell (Endogenous TrkC expression in U2OS)
    Specification Endogenous TrkC expression in U2OS
    Fixative Formaldehyde
    Permeabilization Yes - 3% milk powder+0.1% Triton X-100 in PBS
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 22°C
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    提交于 Nov 19 2008

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"