The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明Is unsuitable for WB.
功能Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
组织特异性Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Contains 1 protein kinase domain.
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Anti-TrkB antibody 图像
Immunohistochemistry - TrkB antibody (ab43079)
The cryostat section of the rat spinal cord was incubated in rabbit polyclonal antibodies to the extracellular domain of mouse TrkB at the dilution of 1/3000 overnight followed with a biotinylated secondary antibodies and ABC kit. The section was developed in diaminobenzidine solution and enhanced in the presence of nickel sulphate. Nerve fibres in the ventral horn are stained.
Anti-TrkB antibody (ab43079)参考文献
has not yet been referenced specifically in any publications.