概述

  • 产品名称Anti-TRKA+B抗体[1.A.37]
  • 描述
    小鼠单克隆抗体[1.A.37] to TRKA+B
  • 特异性Recognizes TrKA/trKB Receptors.
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Purified trKB receptors from insect cells (sf9) transfected with Baculovirus.

性能

应用

Our Abpromise guarantee covers the use of ab18137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 92 kDa.
IP Use at an assay dependent dilution.

靶标

  • 相关性Neurotrophins activate tyrosine kinase receptors of the TRK family (TRKA, TRKB and TRKC) and they all share a common low affinity receptor (p75NTR or p75). Although p75NTR does not appear to directly transduce NGF signals, this receptor appears to increase the responsiveness of the TRK receptors and plays a role in the retrograde transport of neurotrophin signals from axon terminals to the cell body. The expression of trk gene neurotrophin receptors in mouse is tabulated by Barbacid (1994). NGF binds with high affinity and activates the TRKA tyrosine kinase receptor, which is apparently responsible for signal transduction. BDNF activates the TRKB tyrosine kinase receptor, which it shares with NT-4. NT-3 activates the TrkC tyrosine kinase receptor, but can also activate TRKA and TRKB receptors in certain cell systems. NT-4 primarily activates the TRKB tyrosine kinase receptor, which it shares with BDNF.
  • 细胞定位Plasma membrane
  • 数据库链接
  • 别名
    • MTC antibody
    • Neurotrophic tyrosine kinase receptor type 1 antibody
    • Neurotrophin receptor tyrosine kinase type 2 antibody
    • NTRK1 antibody
    • NTRK2 antibody
    • TRK antibody
    • TRKA antibody
    • TRKB antibody
    • Tyrosine kinase receptor A antibody
    • Tyrosine kinase receptor B antibody
    see all

Anti-TRKA+B antibody [1.A.37] (ab18137)参考文献

This product has been referenced in:

See 1 Publication for this product

Product Wall

Thank you for your enquiry. Ab18137 recognizes both TrkA and TrkB receptors and is very weakly reactive with TrkC. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work ...

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Thank you for your enquiry and for providing further information about your experiments. We are very sorry to hear that you are experiencing problem with this antibody. We would like to emphasize that ab18137 has been characterised for Western blot...

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Thank you for your enquiry. The immunogen for this monoclonal antibody was whole purified Trk receptors. The epitopes have not been analyzed, Sorry not to be of more help. Best Regards.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"