概述

性能

应用

Our Abpromise guarantee covers the use of ab58373 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 50 kDa.
ICC/IF Use a concentration of 35 µg/ml.

靶标

  • 功能Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
  • 组织特异性Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
  • 序列相似性Belongs to the zyxin/ajuba family.
    Contains 3 LIM zinc-binding domains.
  • 结构域The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
  • 翻译后修饰Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
  • 细胞定位Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC10556 antibody
    • MGC10558 antibody
    • MGC29959 antibody
    • MGC3837 antibody
    • MGC4423 antibody
    • OIP-1 antibody
    • OIP1 antibody
    • OPA interacting protein 1 antibody
    • OPA-interacting protein 1 antibody
    • Thyroid hormone receptor interactor 6 antibody
    • Thyroid receptor interacting protein 6 antibody
    • Thyroid receptor-interacting protein 6 antibody
    • TR-interacting protein 6 antibody
    • TRIP-6 antibody
    • Trip6 antibody
    • TRIP6_HUMAN antibody
    • TRIP6i2 antibody
    • ZRP 1 antibody
    • ZRP-1 antibody
    • Zyxin-related protein 1 antibody
    see all

Anti-TRIP6 antibody 图像



  • Predicted band size : 50 kDa
    TRIP6 antibody (ab58373) at 1ug/lane + HeLa cell lysate at 25ug/lane.
  • ab58373 at 35 ug/ml staining TRIP6 in human Hella cells by Immunocytochemistry/ Immunofluorescence.

Anti-TRIP6 antibody (ab58373)参考文献

ab58373 has not yet been referenced specifically in any publications.

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