概述

  • 产品名称Anti-TRIP15抗体
    参阅全部 TRIP15 一抗
  • 描述
    山羊多克隆抗体to TRIP15
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide: LNSLNQAVVSKLA, corresponding to C terminal amino acids 421-443 of Human TRIP15.

  • 阳性对照
  • 常规说明GenBank Accession Number – NP_004227. Gene Ontology terms - protein binding; signal transducer activity; signal transduction; transcription from Pol II promoter; cytoplasm; signalosome complex. LocusLink ID - 9318 (human); 12848 (mouse); 261736 (rat).

性能

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应用

Our Abpromise guarantee covers the use of ab4537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 - 5 µg/ml.
WB Use a concentration of 0.03 - 3 µg/ml. Predicted molecular weight: 51 kDa.Can be blocked with Human TRIP15 peptide (ab23046).

靶标

  • 功能Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • 序列相似性Belongs to the CSN2 family.
    Contains 1 PCI domain.
  • 翻译后修饰Phosphorylated by CK2 and PKD kinases.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALIEN antibody
    • Alien Drosophila himolog of antibody
    • Alien homolog antibody
    • COP 9 antibody
    • COP9 antibody
    • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody
    • COP9 constitutive photomorphogenic homolog subunit 2 antibody
    • COP9 signalosome complex subunit 2 antibody
    • COPS 2 antibody
    • Cops2 antibody
    • CSN2 antibody
    • CSN2_HUMAN antibody
    • JAB1 containing signalosome subunit 2 antibody
    • JAB1-containing signalosome subunit 2 antibody
    • SGN 2 antibody
    • SGN2 antibody
    • Signalosome subunit 2 antibody
    • Thyroid Hormone Receptor Interactor15 antibody
    • Thyroid Hormone Receptor Interactor 15 antibody
    • Thyroid receptor-interacting protein 15 antibody
    • TR-interacting protein 15 antibody
    • TRIP 15 antibody
    • TRIP-15 antibody
    • TRIP15 antibody
    see all

Anti-TRIP15 antibody 图像

  • Anti-TRIP15 antibody (ab4537) at 0.03 µg/ml + NIH-3T3 cell lysate at 30 µg
    Developed using the ECL technique

    Predicted band size : 51 kDa
  • ab4537 (3-5 µg/ml) staining TRIP15 in paraffin-embedded sections of Human thyroid Gland.

Anti-TRIP15 antibody (ab4537)参考文献

This product has been referenced in:
  • Lockwood WW  et al. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. PLoS One 8:e63610 (2013). WB . Read more (PubMed: 23658844) »

See 1 Publication for this product

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