概述

  • 产品名称Anti-TRIP15抗体
    参阅全部 TRIP15 一抗
  • 描述
    兔多克隆抗体to TRIP15
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Xenopus laevis, Chimpanzee, Drosophila melanogaster, Zebrafish, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • 免疫原

    Synthetic peptide corresponding to TRIP15. The epitope recognized by ab10462 maps to a region between residues 275 and 325 of human TRIP15.
    Database link: P61201

  • 阳性对照

性能

应用

Our Abpromise guarantee covers the use of ab10462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa).

靶标

  • 功能Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • 序列相似性Belongs to the CSN2 family.
    Contains 1 PCI domain.
  • 翻译后修饰Phosphorylated by CK2 and PKD kinases.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
    see all
  • 别名
    • ALIEN antibody
    • Alien Drosophila himolog of antibody
    • Alien homolog antibody
    • COP 9 antibody
    • COP9 antibody
    • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody
    • COP9 constitutive photomorphogenic homolog subunit 2 antibody
    • COP9 signalosome complex subunit 2 antibody
    • COPS 2 antibody
    • Cops2 antibody
    • CSN2 antibody
    • CSN2_HUMAN antibody
    • JAB1 containing signalosome subunit 2 antibody
    • JAB1-containing signalosome subunit 2 antibody
    • SGN 2 antibody
    • SGN2 antibody
    • Signalosome subunit 2 antibody
    • Thyroid Hormone Receptor Interactor15 antibody
    • Thyroid Hormone Receptor Interactor 15 antibody
    • Thyroid receptor-interacting protein 15 antibody
    • TR-interacting protein 15 antibody
    • TRIP 15 antibody
    • TRIP-15 antibody
    • TRIP15 antibody
    see all

Anti-TRIP15 antibody 图像


  • Developed using the ECL technique

    Predicted band size : 52 kDa


    Exposure time : 30 seconds

    Samples: Whole cell lysate (50 μg - E; 10 μg - T) from mock transfected (E) or TRIP15 transfected (T) HEK293T cells. Antibody used at the indicated concentration.

Anti-TRIP15 antibody (ab10462)参考文献

ab10462 has not yet been referenced specifically in any publications.

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