Anti-TRIO抗体(ab121273)

概述

  • 产品名称Anti-TRIO抗体
    参阅全部 TRIO 一抗
  • 描述
    兔多克隆抗体to TRIO
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 2556-2678 of Human TRIO.

  • 阳性对照
    • Human duodenum tissue.

性能

应用

Our Abpromise guarantee covers the use of ab121273 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
  • 组织特异性Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 CRAL-TRIO domain.
    Contains 2 DH (DBL-homology) domains.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 PH domains.
    Contains 1 protein kinase domain.
    Contains 2 SH3 domains.
    Contains 4 spectrin repeats.
  • 结构域The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers.
  • 翻译后修饰Phosphorylated on serine residue(s).
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARHGEF23 antibody
    • PTPRF-interacting protein antibody
    • tgat antibody
    • trio antibody
    • TRIO_HUMAN antibody
    • Triple functional domain protein antibody
    see all

Anti-TRIO antibody 图像

  • ab121273 at 1/50 dilution staining TRIO in Paraffin-embedded Human Duodenum tissue by Immunohistochemistry.

Anti-TRIO antibody (ab121273)参考文献

ab121273 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

According to the database of Uniprot, there are 5 different isoforms for Human TRIO. Based on the immunogen sequence of ab121273, it is expected that ab121273 can recognize isoform 1, 2, 3, 4. Below is The predic...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"