Anti-TRIM5 gamma抗体(ab17203)

概述

  • 产品名称Anti-TRIM5 gamma抗体
    参阅全部 TRIM5 gamma 一抗
  • 描述
    兔多克隆抗体to TRIM5 gamma
  • 经测试应用适用于: IHC-P, ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human) (C terminal).

  • 阳性对照
    • Human bladder and colon cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab17203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 2 µg/ml.
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 35 kDa.

靶标

  • 功能Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • 结构域The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • 翻译后修饰Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).
  • 细胞定位Cytoplasm > P-body. Cytoplasmic bodies.
  • Information by UniProt
  • 数据库链接
  • 别名
    • RING finger protein 88 antibody
    • RNF88 antibody
    • TRIM5 antibody
    • TRIM5_HUMAN antibody
    • Tripartite motif containing 5 antibody
    • Tripartite motif protein TRIM5 antibody
    • Tripartite motif-containing protein 5 antibody
    see all

Anti-TRIM5 gamma antibody 图像

  • Immunofluorescence of TRIM5 gamma in Human bladder tissue with ab17203 at 20 ug/mL.

  • All lanes : Anti-TRIM5 gamma antibody (ab17203) at 2 µg/ml

    Lane 1 : Human bladder cell lysate
    Lane 2 : Human colon cell lysate


    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
    Detection of TRIM5 gamma in human bladder (A) and colon (B) cell lysates. ab17203 used at 2 ug/ml. Band of ~35 kDa detected. 
  • ab17203 at 2µg/ml staining TRIM5 gamma in human bladder tissue by IHC

Anti-TRIM5 gamma antibody (ab17203)参考文献

ab17203 has not yet been referenced specifically in any publications.

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