Anti-TRIM5 gamma抗体(ab109763)

概述

  • 产品名称Anti-TRIM5 gamma抗体
    参阅全部 TRIM5 gamma 一抗
  • 描述
    兔多克隆抗体to TRIM5 gamma
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH corresponding to 15 amino acids near the carboxy-terminus of Human TRIM5 gamma.

  • 阳性对照
    • Human Small Intestine and Human Pancreas tissue. Human bladder and colon cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab109763 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 40 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • 结构域The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • 翻译后修饰Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).
  • 细胞定位Cytoplasm > P-body. Cytoplasmic bodies.
  • Information by UniProt
  • 数据库链接
  • 别名
    • RING finger protein 88 antibody
    • RNF88 antibody
    • TRIM5 antibody
    • TRIM5_HUMAN antibody
    • Tripartite motif containing 5 antibody
    • Tripartite motif protein TRIM5 antibody
    • Tripartite motif-containing protein 5 antibody
    see all

Anti-TRIM5 gamma antibody 图像

  • All lanes : Anti-TRIM5 gamma antibody (ab109763) at 2 µg/ml

    Lane 1 : Human bladder lysate
    Lane 2 : Human colon lysate


    Predicted band size : 40 kDa
  • ab109763, at 2.5 µg/ml, staining TRIM5 gamma in formalin-fixed, paraffin-embedded Human Small Intestine tissue by immunohistochemistry. Sections were incubated with a biotinylated goat anti-rabbit IgG secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
  • ab109763, at 2.5 µg/ml, staining TRIM5 gamma in formalin-fixed, paraffin-embedded Human pancreas tissue by immunohistochemistry. Sections were incubated with a biotinylated goat anti-rabbit IgG secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-TRIM5 gamma antibody (ab109763)参考文献

ab109763 has not yet been referenced specifically in any publications.

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