Anti-TRIM5 alpha抗体(ab94470)

概述

  • 产品名称Anti-TRIM5 alpha抗体
    参阅全部 TRIM5 alpha 一抗
  • 描述
    兔多克隆抗体to TRIM5 alpha
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 36-85 (QACLTANHKK SMLDKGESSC PVCRISYQPE NIRPNRHVAN LVEKLREVKL) of Human TRIM5 alpha (NP_149023).

  • 阳性对照
    • PANC1 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab94470 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • 结构域The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
  • 翻译后修饰Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).
  • 细胞定位Cytoplasm > P-body. Cytoplasmic bodies.
  • Information by UniProt
  • 数据库链接
  • 别名
    • RING finger protein 88 antibody
    • RNF88 antibody
    • TRIM5 antibody
    • TRIM5_HUMAN antibody
    • tripartite motif protein TRIM5 antibody
    • Tripartite motif-containing protein 5 antibody
    see all

Anti-TRIM5 alpha antibody 图像

  • Anti-TRIM5 alpha antibody (ab94470) at 1 µg/ml (in 5% skim milk / PBS buffer) + PANC1 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 56 kDa

Anti-TRIM5 alpha antibody (ab94470)参考文献

ab94470 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab94470.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"