概述

  • 产品名称Anti-TRIM32抗体
    参阅全部 TRIM32 一抗
  • 描述
    小鼠单克隆抗体to TRIM32
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: RRLPRQFCRS CGLVLCEPCR EADHQPPGHC TLPVKEAAEE RRRDFGEKLT RLRELMGELQ RRKAALEGVS KDLQARYKAV LQEYGHEERR VQDELARSRK , corresponding to amino acids 105-205 of Human TRIM32

性能

应用

Our Abpromise guarantee covers the use of ab56907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.
    • 组织特异性Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.
    • 通路Protein modification; protein ubiquitination.
    • 疾病相关Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. Note=The disease is caused by mutations affecting the gene represented in this entry.
      Bardet-Biedl syndrome 11 (BBS11) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry.
    • 序列相似性Belongs to the TRIM/RBCC family.
      Contains 1 B box-type zinc finger.
      Contains 5 NHL repeats.
      Contains 1 RING-type zinc finger.
    • 翻译后修饰Ubiquitinated.
    • 细胞定位Cytoplasm. Localized in cytoplasmic bodies, often located around the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 72 kda Tat interacting Protein antibody
      • 72 kDa Tat-interacting protein antibody
      • BBS11 antibody
      • E3 ubiquitin-protein ligase TRIM32 antibody
      • HT2A antibody
      • LGMD2H antibody
      • Limb girdle muscular dystrophy 2H (autosomal recessive) antibody
      • Limb girdle muscular dystrophy 2H antibody
      • Muscular dystrophy Hutterite type antibody
      • TAT interactive protein 72KD antibody
      • TATIP antibody
      • TRI32_HUMAN antibody
      • Trim32 antibody
      • Tripartite Motif Containing Protein 32 antibody
      • Tripartite motif-containing protein 32 antibody
      • Zinc finger protein HT2A antibody
      see all

    Anti-TRIM32 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56907 TRIM32 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-TRIM32 antibody (ab56907)参考文献

    ab56907 has not yet been referenced specifically in any publications.

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