Anti-TRIM3抗体(ab111840)
Key features and details
- Rabbit polyclonal to TRIM3
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-TRIM3抗体 -
描述
兔多克隆抗体to TRIM3 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat -
免疫原
Synthetic peptide corresponding to Human TRIM3 (N terminal). NP_006449
Database link: O75382 -
阳性对照
- Human fetal heart, Human fetal brain, 293T, RAW264.7 and LoVo lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute in 200ul Sterile Distilled Water. -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab111840 is purified by a peptide affinity column. -
克隆
多克隆 -
同种型
IgG
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111840于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/2000. Detects a band of approximately 81 kDa.
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说明 |
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WB
1/1000 - 1/2000. Detects a band of approximately 81 kDa. |
靶标
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相关性
TRIM3 a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM3 localizes to cytoplasmic filaments and is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. -
细胞定位
Cytoplasmic; Early endosome -
数据库链接
- Entrez Gene: 10612 Human
- Entrez Gene: 55992 Mouse
- Entrez Gene: 83616 Rat
- Omim: 605493 Human
- SwissProt: O75382 Human
- SwissProt: Q9R1R2 Mouse
- SwissProt: O70277 Rat
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别名
- BERP antibody
- Brain expressed RING finger protein antibody
- FLJ16135 antibody
see all
图片
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All lanes : Anti-TRIM3 antibody (ab111840) at 1/1000 dilution
Lane 1 : Human fetal brain lysate
Lane 2 : Human fetal heart lysate
Lane 3 : 293T lysate
Lane 4 : RAW264.7 lysate
Lane 5 : LoVo lysate
Observed band size: 81 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab111840 被引用在 4 文献中.
- Esposito D et al. Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity. Nat Commun 13:7583 (2022). PubMed: 36481767
- Song Y et al. miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3. Biochem Biophys Res Commun 516:872-879 (2019). PubMed: 31270028
- Li Y et al. miR-4513 promotes breast cancer progression through targeting TRIM3. Am J Transl Res 11:2431-2438 (2019). PubMed: 31105849
- Lu Q et al. TRIM3 Negatively Regulates Autophagy Through Promoting Degradation of Beclin1 in Ewing Sarcoma Cells. Onco Targets Ther 12:11587-11595 (2019). PubMed: 32021240