Anti-TRIM11抗体(ab111694)

概述

• 产品名称Anti-TRIM11抗体
  参阅全部 TRIM11 一抗
• 描述
  兔多克隆抗体to TRIM11
• 经测试应用适用于: IHC-P, WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Cow
• 免疫原

  Recombinant fragment, corresponding to a region within amino acids 1-155 of Human TRIM11.

• 阳性对照
  • 293T, A431, Jurkat and Raji whole cell lysates; Human Hepatoma tissue.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液pH: 7.00
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
• Concentration information loading...
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Other

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteasome / Ubiquitin
  • Ubiquitin E3 Enzymes
  • RING Finger E3 Ligase

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Raji whole cell lysate (ab30124)
  • Jurkat whole cell lysate (ab7899)
  • A431 whole cell lysate (ab7909)

应用

靶标

• 功能E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
• 组织特异性Ubiquitous.
• 通路Protein modification; protein ubiquitination.
• 序列相似性Belongs to the TRIM/RBCC family.
  Contains 1 B box-type zinc finger.
  Contains 1 B30.2/SPRY domain.
  Contains 1 RING-type zinc finger.
• 结构域The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
  The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.
• 细胞定位Cytoplasm. Nucleus.

• Target information above from: UniProt accession Q96F44 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 81559 Human
  • Entrez Gene: 338364 Mouse
  • Entrez Gene: 94091 Mouse
  • Entrez Gene: 360534 Rat
  • Omim: 607868 Human
  • SwissProt: Q96F44 Human
  • SwissProt: Q99PQ2 Mouse
  • SwissProt: B1H278 Rat

  • Unigene: 13543 Human
  • Unigene: 248049 Mouse
  • Unigene: 439976 Mouse
  • Unigene: 9308 Rat

  see all
• 别名
  • BIA 1 antibody
  • BIA1 antibody
  • E3 ubiquitin protein ligase TRIM11 antibody

  • E3 ubiquitin-protein ligase TRIM11 antibody
  • Protein BIA1 antibody
  • RING finger protein 92 antibody
  • RING type E3 ubiquitin transferase TRIM11 antibody
  • RNF 92 antibody
  • RNF92 antibody
  • TRI11_HUMAN antibody
  • Trim 11 antibody
  • TRIM11 antibody
  • Tripartite motif containing 11 antibody
  • tripartite motif protein 11 antibody
  • Tripartite motif-containing protein 11 antibody

  see all